Lineage B.1.1.248


Variant of the SARS-CoV-2 virus

Lineage B.1.1.248, colloquially known as the Brazil(ian) coronavirus variant,[1][2][3] is one of the variants of SARS-CoV-2, the virus that causes COVID-19.[4] This variant of SARS-CoV-2 was first detected by the National Institute of Infectious Diseases (NIID), Japan, on 6 January 2021 in four people who had arrived in Tokyo having visited Amazonas, Brazil four days earlier.[3][5] The Brazilian state-run Oswaldo Cruz Foundation has confirmed its belief that the variant had been circulating in the Amazon rain forest,[6] where it is believed to have been in circulation since July 2020.[7]

A preprint of a paper by Carolina M Voloch et al. describes relationships between Brazillian samples sequenced during 2020 and identified a novel lineage of SARS-CoV-2, ‘B.1.1.248’, in circulation in Brazil, which originated from B.1.1.28. It describes it as first emerging in July and first detected by themselves in October, but as of publishing (December 2020), although significantly increased in frequency, still largely confined to the state capital of Rio de Janeiro.[8] In May the majority of their samples had been of lineage B.1.1.33 whereas by September there was significant spread of B.1.1.28, and during October and November the novel variant lineage (B.1.1.248) predominated over respectively 3 and 4 other classifications using the Pangolin tool.[9] The paper identifies the change E484K (present in both B.1.1.28 and B.1.1.248) as “widely spread” across the samples (for example, 36 out of the 38 samples in one set).[9]


  • 1 Mutations
  • 2 Detection
  • 3 Statistics
  • 4 See also
  • 5 References


This variant of SARS-CoV-2 has 12 mutations in its spike protein, including N501Y and E484K.[3]


The isolate of the new variant was submitted to GISAID having been assigned the ID range: EPI_ISL_792680 to EPI_ISL_792683.[10]


See also[edit]

  • Variants of SARS-CoV-2


  • ^ Covid-19: Brazil virus already in UK ‘not variant of concern’, scientist says 15 January 2021 accessed 15 January 2021
  • ^ COVID-19: Virologist says Brazilian coronavirus variant detected in UK is not the one ‘of concern’ 15 January 2021 accessed 15 January 2021
  • ^ a b c .mw-parser-output cite.citation{font-style:inherit}.mw-parser-output .citation q{quotes:”””””””‘””‘”}.mw-parser-output .id-lock-free a,.mw-parser-output .citation .cs1-lock-free a{background:linear-gradient(transparent,transparent),url(“//”)right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited a,.mw-parser-output .id-lock-registration a,.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:linear-gradient(transparent,transparent),url(“//”)right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription a,.mw-parser-output .citation .cs1-lock-subscription a{background:linear-gradient(transparent,transparent),url(“//”)right 0.1em center/9px no-repeat}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-ws-icon a{background:linear-gradient(transparent,transparent),url(“//”)right 0.1em center/12px no-repeat}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-maint{display:none;color:#33aa33;margin-left:0.3em}.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}Lovett, Samuel (14 January 2021). “What we know about the new Brazilian coronavirus variant”. The Independent. London. Retrieved 14 January 2021.
  • ^ Third concerning coronavirus variant should be a ‘wake up call’ to the world, experts warn 12 January 2021, accessed 17 January 2021
  • ^ “Japan finds new coronavirus variant in travelers from Brazil”. Japan Today. Japan. 11 January 2021. Retrieved 14 January 2021.
  • ^ Tony Winterburn (13 January 2021). “Brazil Confirms The Circulation Of A New ‘Amazon Rain Forest’ Variant Of The Coronavirus”. Retrieved 14 January 2021.
  • ^ How worrying are the UK, South Africa, and Brazil Covid variants? Michelle Roberts, Accessed 15 January 2021
  • ^ Genomic characterization of a novel SARS-CoV-2 lineage from Rio de Janeiro, Brazil (Abstract) Carolina M Voloch et al. via, accessed 15 January 2021
  • ^ a b Voloch, Carolina M.; et al. (2020). “Genomic characterization of a novel SARS-CoV-2 lineage from Rio de Janeiro, Brazil” full text (see figure 5). Retrieved 15 January 2021. doi:10.1101/2020.12.23.20248598 – via Medarxiv.
  • ^ “Supplementary Table 1 Acknowledgement Table GISAID” (PDF). GISAID. 14 January 2021. p. 10. Retrieved 14 January 2021. EPI_ISL_792680, EPI_ISL_792681, EPI_ISL_792682, EPI_ISL_792683 – Pathogen Genomics Center, National Institute of Infectious Diseases Pathogen Genomics Center, National Institute of Infectious Diseases – Tsuyoshi Sekizuka, Kentaro Itokawa, Rina Tanaka, Masanori Hashino, Makoto Kuroda
  • ^ “Brief report: New Variant Strain of SARS-CoV-2 Identified in Travelers from Brazil” (PDF) (Press release). Japan: NIID (National Institute of Infectious Diseases). 12 January 2021. Retrieved 14 January 2021.
  • ^ “新たなコロナ変異種を確認 ブラジルから入国の4人” [New coronavirus Mutation Confirmed in 4 people from Brazil]. The Nikkei (in Japanese). Japan. 10 January 2020. Retrieved 14 January 2021. 厚生労働省は10日、ブラジルから羽田空港に2日に到着した10~40代の男女4人が、新型コロナウイルスでこれまで確認されていないタイプの変異種に感染していたと発表した。国内での変異種への感染確認は計34人になった (The Ministry of Health, Labor and Welfare announced on the 10th that four men and women in their teens and 40s who arrived at Haneda Airport from Brazil on the 2nd were infected with a type of mutation that had not been confirmed so far with the new coronavirus.)
  • ^ Biernath, André (14 January 2021). “Coronavirus: qué se sabe sobre la nueva variante encontrada en Brasil (y que llegó a Japón)” [Coronavirus: what is known about the new variant found in Brazil (and that reached Japan)]. BBC Brasil (in Spanish). Sao Paulo. Retrieved 18 January 2021. Los científicos analizaron el material genético de 31 muestras de pacientes con covid-19 en la ciudad de Manaos… …De ellos, 13 individuos (el 42% del total) presentaban justamente ese nuevo linaje del virus. Scientists analyzed the genetic material of 31 samples from patients with covid-19 in the city of Manaus… …Of them, 13 individuals (42% of the total) presented precisely this new lineage of the virus.
  • ^ “S. Korea reports 1st COVID-19 variant case from Brazil”. Yonhap News Agency. 18 January 2021. Retrieved 20 January 2021.
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